Karen Davis (Sarah Michelle Gellar) is an American nurse living and working in Tokyo. She is efficient and hardworking and therefore she handles already numerous assignments, but her boss Alex (Ted Raimi) asks her to take one more patient, an aged American woman named Emma Williams (Grace Zabriskie). Emma lives alone in a large and old (by Tokyo's standards) house and she needs care because she suffers from dementia and lethargy - or Yoko (Yoko Maki), the usually very reliable previous nurse assigned to her didn't report to work for a couple of days...