Enola Holmes is being hunted by the world's most famous detective - her own brother, Sherlock Holmes. But for the sake of her and her mother's freedom, she must elude him. While she is on the run, Enola discovers a hidden cache of charcoal drawings; and the girl who drew them - Lady Cecily - has disappeared without a trace. Enola must unravel the clues to find this left-handed lady, but in order to save her, she risks revealing her own identity and losing her freedom forever!