When a woman arrives home to her Manhattan apartment to find that her personal items have been rearranged while she slept, police initially dismiss her complaint. Nothing was stolen, and there's no sign of breaking and entering. But when the same woman turns up dead, Lincoln Rhyme and Amelia Sachs are brought in to investigate the murder. The soon learn that the murderer calls himself "the Locksmith." He is obsessed with locks, slipping into homes in the dead of night and tying his victims up with knots or locks, ultimately strangling them.